Hemodynamic Effect of the Metallopurpurin Snet2 and Light on Transplantable Fanft Induced Bladder Tumor
- 1 March 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 143 (3), 630-633
- https://doi.org/10.1016/s0022-5347(17)40044-9
Abstract
Changes in blood flow to transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide induced bladder tumors growing subcutaneously in the flanks of Fischer CDF (F344/CrlBR) rats were meausred after photodynamic therapy with the photosensitizer tin (II) etiopurpurin dichloride using the radioactive microsphere technique. As with the other photosensitizers, hematoporphyrin derivative and chloroaluminum tetrasulfophtalocyanine, tin (II) etiopurpurin dichloride and light caused a rapid decrease in tumor blood flow in this tumor model. The decrease in blood flow occurred whether the vehicle for photosensitizer delivery was emulsion or a liposome. Systemic heparinization of animals prior to light treatment did not alter changes in tumor blood flow.This publication has 11 references indexed in Scilit:
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