ANTIBODIES TO GAMMA-GLOBULIN IN INFANTS AND CHILDREN EXPOSED TO ISOLOGOUS GAMMA-GLOBULIN
- 1 February 1965
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 35 (2), 229-235
- https://doi.org/10.1542/peds.35.2.229
Abstract
Isoantibodies directed against human gamma-globulin were found in children receiving single and repeated injections of gamma-globulin and in those who had received blood transfusions at birth. Nine of 14 children receiving repeated gamma-globulin injections had anti-gamma-globulin antibodies. One-third of all children exposed to gamma-globulin by transfusion or injection, but only 6% of unexposed children had anti-gamma-globulin antibodies. Females appear to have a higher incidence of sensitization than males. The possibility exists that these antibodies may be implicated in reported anaphylactic reactions to gamma-globulin.Keywords
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