Genetic Control of Immune Responsiveness to a Glutamic Acid, Alanine, Tyrosine Copolymer in Mice

Abstract

Mice of various strains were immunized with a random terpolymer of glutamic acid₆₀ alanine₃₀ tyrosine₁₀ (GAT₁₀). The ability to produce significant anti-GAT₁₀ antibody, detected by an antigen-binding assay, was possessed by mice of H-2^a, H-2^b, H-2^d, H-2^k histocompatibility alleles. Mice with H-2^p and H-2^s alleles were non-responders. Congenic mice that differed only at the H-2 locus responded according to their H-2 type.