Stimulation of testicular protein synthesis in vivo by gonadotrophins and growth hormone in hypophysectomized adult mice

Abstract

The effects of FSH, HCG, GH [follicle-stimulating hormone, human chorionic gonadototropin and growth hormone, respectively] and testosterone on testicular protein synthesis were investigated in hypophysectomized adult mice by measuring incorporation of 3H-lysine into acid-precipitable material. The incorporation per mg protein was increased by FSH, HCG and GH but decreased by testosterone. The maximum effect of FSH occurred between 8-14 h after administration of the hormone, much later than found in vitro for the rat.