Butirosin, a New Aminoglycosidic Antibiotic Complex: Isolation and Characterization
- 1 August 1972
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 2 (2), 84-88
- https://doi.org/10.1128/aac.2.2.84
Abstract
Butirosin, a new water-soluble aminoglycosidic antibiotic complex, active against gram-positive and gram-negative bacteria, has been isolated from fermentation filtrates of Bacillus circulans by ion exchange. The complex has been resolved into isomeric A and B components, C 21 H 41 N 5 O 12 , by means of Dowex 1 × 1 or Dowex 1 × 2 chromatography. Properties of the free bases and the N, N′, N″, N‴ -tetraacetyl derivatives of butirosin A and B are given.Keywords
This publication has 1 reference indexed in Scilit:
- Butirosin, a New Aminoglycosidic Antibiotic Complex: Antibacterial Activity In Vitro and in MiceAntimicrobial Agents and Chemotherapy, 1972