Leptin Induces Endothelial Cell Migration Through Akt, Which Is Inhibited by PPARγ-Ligands
- 1 November 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 40 (5), 748-754
- https://doi.org/10.1161/01.hyp.0000035522.63647.d3
Abstract
Migration of endothelial cells (EC) is a key event in angiogenesis that contributes to neovascularization in diabetic vasculopathy. Leptin induces angiogenesis and is elevated in obesity and hyperi...Keywords
This publication has 30 references indexed in Scilit:
- PTEN Modulates Vascular Endothelial Growth Factor-Mediated Signaling and Angiogenic EffectsJournal of Biological Chemistry, 2002
- Peroxisome Proliferator–Activated Receptor-γ Ligands Inhibit Nuclear but Not Cytosolic Extracellular Signal–Regulated Kinase/Mitogen–Activated Protein Kinase–Regulated Steps in Vascular Smooth Muscle Cell MigrationJournal of Cardiovascular Pharmacology, 2001
- Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3‐kinase‐, Rho‐, and Rac‐dependent signaling pathwaysThe FASEB Journal, 2000
- LeptinAnnual Review of Physiology, 2000
- Regulation of Gene Expression by Activation of the Peroxisome Proliferator-Activated Receptor γ with Rosiglitazone (BRL 49653) in Human AdipocytesBiochemical and Biophysical Research Communications, 1999
- Roles of Extracellular Signal‐regulated Kinase 1/2 and p38 Mitogen‐activated Protein Kinase in the Signal Transduction of Basic Fibroblast Growth Factor in Endothelial Cells during AngiogenesisJapanese Journal of Cancer Research, 1999
- PPARγ-Ligands Inhibit Migration Mediated by Multiple Chemoattractants in Vascular Smooth Muscle CellsJournal of Cardiovascular Pharmacology, 1999
- Leptin Regulation of Peroxisome Proliferator-Activated Receptor-γ, Tumor Necrosis Factor, and Uncoupling Protein-2 Expression in Adipose TissuesBiochemical and Biophysical Research Communications, 1998
- Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.Journal of Clinical Investigation, 1996
- Induction of human vascular endothelial stress fibres by fluid shear stressNature, 1984