The Role of Protein Synthesis on the Generation of Tissue Factor Activity by Leukocytes

Abstract

Peripheral leukocytes incubated with adsorbed serum and endotoxin generate procoagulant (tissue factor) activity. The generation of tissue factor activity is inhibited if actinomycin D, cycloheximide, or puromycin are added at the beginning of the incubation but no inhibition occurs if actinomycin D or cycloheximide are added after 2 hr incubation.