Cellular site of opiate dependence
- 1 February 1980
- journal article
- Published by Springer Nature in Nature
- Vol. 283 (5748), 625-629
- https://doi.org/10.1038/283625a0
Abstract
Experiments on whole animals, guinea pig isolated ileum, individual neurones in situ and cultured neuroblastoma--glioma hybrid cells indicate that opiate dependence and associated tolerance develop within neurones bearing specific opiate receptors (opiate-sensitive neurones). The essential change appears to be an hypertrophy of the cyclic AMP system, in response to inhibition by opiate of a neuronal adenylate cyclase.Keywords
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