Neuromyelitis Optica Treatment
- 1 September 2010
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 67 (9), 1131-6
- https://doi.org/10.1001/archneurol.2010.203
Abstract
To analyze treatment response in Brazilian patients with neuromyelitis optica. Retrospective review. Neuroimmunology Clinic of the Federal University of São Paulo, São Paulo, Brazil. Patients Thirty-six patients with relapsing-remitting optic-spinal disease; long, extending spinal cord lesions; and brain magnetic resonance images not meeting Barkhof criteria for multiple sclerosis, thus fulfilling the 1999 and 2006 criteria for neuromyelitis optica. Patients were followed up from 1994 to 2007. Relapses and accumulation of disability. Mean follow-up time was 47.2 months and mean age at onset was 32.3 years. Sixty-four treatments were implemented in 36 patients, which included interferon beta, methotrexate, cyclophosphamide, prednisone, and azathioprine solely or plus prednisone. Patients who were treated with azathioprine or azathioprine with prednisone had a reduction in the occurrence of relapses and Expanded Disability Severity Scale score stabilization, as opposed to patients who received other treatments. Of the 4 patients who died, only 1 had received azathioprine treatment. Azathioprine as monotherapy or with prednisone seems to have reduced the relapse frequency and halted disability progression in the majority of patients treated, with minor and manageable adverse effects.Keywords
This publication has 25 references indexed in Scilit:
- Treatment of Neuromyelitis Optica With Mycophenolate Mofetil: Retrospective Analysis of 24 PatientsYearbook of Neurology and Neurosurgery, 2010
- Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysisMultiple Sclerosis Journal, 2007
- Variable responses to rituximab treatment in neuromyelitis optica (Devic’s disease)Neurological Sciences, 2007
- Neuromyelitis optica: Changing conceptsJournal of Neuroimmunology, 2007
- Immunosuppressive therapy is more effective than interferon in neuromyelitis opticaMultiple Sclerosis Journal, 2007
- Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic Disease)Archives of Neurology, 2006
- IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channelThe Journal of Experimental Medicine, 2005
- An open label study of the effects of rituximab in neuromyelitis opticaNeurology, 2005
- A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosisThe Lancet, 2004
- Clinical characteristics, course and prognosis of relapsing Devic?s Neuromyelitis OpticaZeitschrift für Neurologie, 2004