The Leucocyte Response in the Rabbit to Pyrogen from Proteus Vulgaris: Part II. Neutrophil and Temperature Responses
- 1 September 1954
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 6 (1), 962-970
- https://doi.org/10.1111/j.2042-7158.1954.tb11031.x
Abstract
Summary: The effect of 4 dose-levels of pyrogen from Proteus vulgaris on the polynuclear count in rabbits has been investigated quantitatively and the effect measured as the percentage fall in the average number of lobes per neutrophil. The simultaneous effect of pyrogen on temperature and on the percentage of small lymphocytes was also recorded. Correlation was found between the 3 effects. The merits of each of these 3 indices of pyrogenic activity have been assessed comparatively. 5 The presence of antibodies to pyrogen could not be demonstrated in rabbits which showed a small degree of tolerance.Keywords
This publication has 5 references indexed in Scilit:
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