To the Editor:— Ulcerative colitis is a systemic disease, frequently involving the skin, eyes, joints, and liver, without affecting other areas of the gastrointestinal tract. A most unusual example of ulcerative colitis associated with ulcerative esophagitis and chronic hepatitis was encountered recently. Report of a Case:— A generalized maculopapular eruption, lymphadenopathy, and splenomegaly developed in a 15-year-old white boy in December 1962; intermittent fever, malaise, and watery diarrhea followed. In January 1964, marked hepatomegaly and cervical and axillary lymphadenopathy were found. The total bilirubin was 5 mg/100 ml, alkaline phosphatase, 22 Bodansky units, and total serum protein, 10.5 gm/100 ml, with a diffusely increased γ-globulin on protein electrophoresis, ranging from 4.5 to 5.1 gm/100 ml (normal 0.6-1.5 gm/ 100 ml). Ultracentrifugation revealed that the γ-globulin was primarily 7S with a normal amount of macroglobulin. The serum glutamic oxaloacetic transaminase level ranged from 400 to 1,000 units. The latex agglutination test