EVALUATION OF 9-a-FLUOROHYDROCORTISONE ACETATE IN THE TREATMENT OF VARIOUS INFLAMMATORY DERMATOSES

Abstract

Recently several derivatives of cortisone acetate and hydrocortisone acetate have been synthetized in which the 9-α-hydrogen atom is replaced by a halogen.^* Data as yet unpublished † have indicated that the 9-α-fluoro-derivative of hydrocortisone acetate possessed approximately 13 times the antiinflammatory activity of hydrocortisone acetate. MATERIALS AND METHODS This paper deals with a clinical evaluation of the effects of 9-α-fluorohydrocortisone acetate in 64 patients with various dermatological conditions in all of whom an inflammatory component was present. 9-α-Fluorohydrocortisone acetate was administered both systemically and locally. Parenteral therapy consisted of the oral administration of 1 mg. tablets in a daily dosage of 1 to 9 mg. Local treatment consisted of the application of lotions or ointments containing 0.1% or 0.2% 9-α-fluorohydrocortisone acetate.‡ Two types of bases were used, one a plasticized petrolatum base § and the other a lotion.‖ In addition, lotions and ointments containing neomycin, 2.5 mg/gm.