A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomesElectronic supplementary information (ESI) available: analytical data for 1, 2 and 3. See http://www.rsc.org/suppdata/cc/b2/b200126h/

Abstract

The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C₁₈H₃₇)₂NCOCH₂OCH₂COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.