IN VITRO DEMONSTRATION OF CELLULAR SENSITIVITY IN ALLERGIC ENCEPHALOMYELITIS
Open Access
- 1 December 1965
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 122 (6), 1161-1171
- https://doi.org/10.1084/jem.122.6.1161
Abstract
Peritoneal cells obtained from animals exhibiting delayed hypersensitivity are inhibited from migrating in vitro by specific sensitizing antigen. This test for the detection of delayed hypersensitivity was applied to the problem of cellular sensitivity in allergic encephalomyelitis (AE). The migration of peritoneal cells obtained from guinea pigs with AE was inhibited specifically by nervous tissue antigens. The specificity of this reaction was further studied. Neonatal rat nervous tissue, which was shown to lack the encephalitogenic antigen, i.e. did not produce AE when injected with complete adjuvant into guinea pigs and rats, did not inhibit the migration of cells from animals with AE. Adult rat nervous tissue, which readily produces AE, and thus contains the encephalitogenic antigen did inhibit the migration of such cells. The finding that cells from animals with AE display hypersensitivity which appears to be directed specifically to the encephalitogenic antigen strongly supports the view that such cells could play an important role in the pathogenesis of this disease.This publication has 16 references indexed in Scilit:
- Immunofluorescent Localization of Encephalitogenic Protein in MyelinThe Journal of Immunology, 1964
- DELAYED HYPERSENSITIVITY IN VITRO .3. SPECIFICITY OF HAPTEN-PROTEIN CONJUGATES IN INHIBITION OF CELL MIGRATION1964
- DELAYED HYPERSENSITIVITY IN VITRO .I. SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS1964
- The Role of Hyperergy in Measles EncephalitisArchives of Pediatrics & Adolescent Medicine, 1962
- A HISTOLOGIC STUDY OF EARLY LESION IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN GUINEA PIG AND RABBIT1962
- Transfėr of Allergic Encephalomyelitis by Lymph Node Cells in Inbred Guinea PigsScience, 1961
- TRANSFER OF ALLERGIC ENCEPHALOMYELITIS IN RATS BY MEANS OF LYMPH NODE CELLSThe Journal of Experimental Medicine, 1960
- Tuberculin Type Sensitivity to Spinal Cord Antigen in Rabbits with Isoallergic EncephalomyelitisThe Journal of Immunology, 1951
- ALLERGIC ENCEPHALOMYELITIS IN MONKEYS IN RESPONSE TO INJECTION OF NORMAL MONKEY NERVOUS TISSUEThe Journal of Experimental Medicine, 1947
- THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTSThe Journal of Experimental Medicine, 1947