Identification of a New Metabolite of Imipramine.
- 1 May 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 110 (1), 187-190
- https://doi.org/10.3181/00379727-110-27462
Abstract
Imipramine-N-oxide (IPNO) has been identified as a metabolite of imipramine. The product was isolated from human urine by solvent extraction and chromatography. Its identity with authentic IPNO was established by their similarity in color reactions and electrophoretic behavior, and by paper chromatography and cochromatography in 8 solvent systems. Approximately 2[degree]/o of administered imipramine is voided as the N-oxide.Keywords
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