CLAUDE BERNARD'S THEORY OF NARCOSIS
- 15 September 1930
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 16 (9), 573-577
- https://doi.org/10.1073/pnas.16.9.573
Abstract
The Over-ton-Meyer theory is accepted as applying to permeability, but not in any proper sense to narcosis. Bernard''s theory of reversible coagulation of the colloids of sensory nerves was verified by photomicrographic studies of live yeast cells treated with 2% amyl alcohol; coagulation and flocculation occurred in 25 min.; the time varied with temp. and concentration of narcotic and culture. Centrifuged treated cultures were revived in fresh media (Laurent''s). Non protein-coagulating gases (N2O) give rise to acid metabolic products which cause flocculation. Bernard''s theory offers a clue to a scientific method of countering habit-forming drugs.This publication has 1 reference indexed in Scilit:
- Reversible Permeability of Membranes and its Relation to Cell MetabolismThe Journal of Physical Chemistry, 1926