Induction of eosinophilic colonies by interleukin-5 on acute myeloblastic leukaemic cells
- 1 February 1990
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 74 (2), 169-172
- https://doi.org/10.1111/j.1365-2141.1990.tb02561.x
Abstract
The effect of interleukin‐5 (IL‐5) on blast colony formation of acute myeloblastic leukaemia (AML) cells was studied. IL‐5 showed a weak but significant colony stimulatory effect in one out of six cases studied. IL‐5 induced eosinophilic colony growth in this case, and chromosomal and histochemical analyses strongly suggested that these eosinophilic colonies were derived from leukaemic blast progenitor cells. To our knowledge, this is the first report that IL‐5 induces eosinophilic colonies on fresh AML cells. A possible induction of differentiation of AML blast cells by IL‐5 is suggested.This publication has 15 references indexed in Scilit:
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