Transcriptional Profiling Reveals Global Defects in Energy Metabolism, Lipoprotein, and Bile Acid Synthesis and Transport with Reversal by Leptin Treatment in Ob/ob Mouse Liver
Open Access
- 1 December 2001
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 276 (52), 49066-49076
- https://doi.org/10.1074/jbc.m107250200
Abstract
No abstract availableKeywords
This publication has 53 references indexed in Scilit:
- Quantitative Expression Analysis of Genes Regulated by Both Obesity and Leptin Reveals a Regulatory Loop between Leptin and Pituitary-derived ACTHPublished by Elsevier ,2000
- LeptinAnnual Review of Physiology, 2000
- Defective HDL particle uptake in ob/ob hepatocytes causes decreased recycling, degradation, and selective lipid uptakeJournal of Clinical Investigation, 2000
- Altered Expression of HepaticCYP2E1andCYP4Ain Obese, Diabeticob/obMice, andfa/faZucker RatsBiochemical and Biophysical Research Communications, 1999
- Increased High Density Lipoprotein (HDL), Defective Hepatic Catabolism of ApoA-I and ApoA-II, and Decreased ApoA-I mRNA inob/ob MiceJournal of Biological Chemistry, 1999
- Hypoglycemia-associated Hyperammonemia Caused by Impaired Expression of Ornithine Cycle Enzyme Genes in C/EBPα Knockout MicePublished by Elsevier ,1998
- The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response factor 1.Journal of Clinical Investigation, 1998
- Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptinNature Genetics, 1996
- Weight-Reducing Effects of the Plasma Protein Encoded by the obese GeneScience, 1995
- Effects of the obese Gene Product on Body Weight Regulation in ob / ob MiceScience, 1995