QUANTITATIVE STUDIES ON EFFECT OF GASTROJEJUNOSTOMY ON GASTRIC SECRETION

Abstract

THE DATA secured in the present investigation establish the surprising fact that certain types of gastroenterostomy in dogs produce a profound stimulation of the secretion of gastric juice by the body and fundus of the stomach. These studies were prompted by the previous observation, in this laboratory, that the Mann-Williamson procedure for the production of experimental stoma ulcers regularly causes a hypersecretion of acid gastric juice.¹ The development in this laboratory of a method for the quantitative collection of gastric juice from isolated stomach pouches of various types for long periods has made it possible to restudy the physiology of gastric secretion and to estimate the relative importance of various stimulating mechanisms on the total amount of gastric secretion produced in a measured interval of time.² With use of these methods it has been determined that 40% of the total output of gastric juice in normal dogs is