Functional activity of 5‐HT2 receptors in the modulation of the sleep/wakefulness states
- 1 September 1992
- journal article
- Published by Wiley in Journal of Sleep Research
- Vol. 1 (3), 163-168
- https://doi.org/10.1111/j.1365-2869.1992.tb00032.x
Abstract
In the light of recent pharmacological investigations using agonists and antagonists that have potent actions on 5-hydroxytryptamine-2 (5-HT2) receptors, the possible functional role of 5-HT2 receptors in the modulation of the sleep/wakefulness states was examined. Data obtained from animals and from clinical studies suggest that serotonin may exert an inhibitory control on deep slow-wave sleep (SWS) through 5-HT2 receptors. In further investigations, the existence of a diurnal variation in the functional activity of 5-HT2 receptors, that depends on the day/night cycle and/or the melatonin rhythm, was revealed. Questions remain with regard to the physiological significance, of the 5-HT2 receptor-mediated deep SWS regulation, the anatomical site(s) of 5-HT2 receptors involved in this regulation and the mechanism underlying diurnal fluctuations in the functional activity of 5-HT2 receptors.Keywords
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