A Genetic Method for Determining the Order of Events in a Biological Pathway
- 1 July 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (7), 2046-2050
- https://doi.org/10.1073/pnas.70.7.2046
Abstract
We describe the application of a simple genetic test that indicates the order of events in a morphogenic or biochemical pathway. The test uses temperature-sensitive (ts) and cold-sensitive (cs) mutants, and it orders the times at which the ts and cs defects are expressed.Keywords
This publication has 18 references indexed in Scilit:
- The behavior of temperature-sensitive T4 DNA polymerase mutants in temperature shift experimentsVirology, 1971
- Temperature-Sensitive Mutations in Drosophila melanogasterScience, 1970
- Reversible inactivation of T4 ts DNA polymerase mutants in vivoVirology, 1970
- Isolation of UGA and UAG nonsense mutants of bacteriophage P22Virology, 1970
- A new class of temperature conditional lethal mutants of bacteriophage T4DMutation Research, 1968
- Synthesis and maturation of phage P22 DNAJournal of Molecular Biology, 1968
- T4 mutants unable to induce deoxycytidylate deaminase activityVirology, 1966
- The properties of repressor and the kinetics of its actionJournal of Molecular Biology, 1965
- Mutations in the temperate phage P22 and lysogeny in SalmonellaVirology, 1957
- SOME RECENT STUDIES BEARING ON THE ONE GENE-ONE ENZYME HYPOTHESISCold Spring Harbor Symposia on Quantitative Biology, 1951