Effect of citric acid-cycle intermediates on oxaloacetate utilization and succinate oxidation
- 1 August 1960
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 76 (2), 293-297
- https://doi.org/10.1042/bj0760293
Abstract
The rate of oxaloacetate utilization by tissue homogenates is inhibited, under certain conditions, by the presence of succinate, L-malate, fumarate and [alpha]-oxoglutarate. The inhibition by the last-named 3 substances potentiates the inhibition by oxaloacetate of succinate oxidation. The role of oxaloacetate as a rate-regulator of oxidative metabolism through the citric acid cycle is discussed.Keywords
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