Markers of chronic inflammation and obesity: a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention
- 17 May 2002
- journal article
- research article
- Published by Springer Nature in International Journal of Obesity
- Vol. 26 (5), 659-662
- https://doi.org/10.1038/sj.ijo.0801970
Abstract
Background: Human adipose tissue expresses and releases proinflammatory cytokines and these measures of chronic inflammation have recently been associated with obesity. Hypothesis: To test whether the proinflammatory state is reversible in subjects undergoing weight loss by surgical measures. Subjects and Methods: Twenty morbidly obese women participated in this prospective study. Subjects were examined for fat mass, high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) before and 1 y after Swedish adjustable gastric banding. Results: Anthropometric measures displayed a significant reduction of the body mass index (BMI) from 41.6±5.4 to 30.8±6.1 kg/m2 and the fat mass from 53.9±10.3 to 29.8±12.1 kg (mean±s.d.). Hs-CRP levels decreased significantly from 1.33±1.21 mg/dl in pre-gastric banding subjects to 0.40±0.61 mg/dl in post-gastric banding subjects, respectively. IL-6 and TNF-α levels did not differ significantly between pre- and post-gastric banding subjects. Conclusions: We speculate that in these patients the marked reduction in C-reactive protein might be beneficial in reducing their cardiovascular risk and is not solely mediated by IL-6 and TNF-α.Keywords
This publication has 22 references indexed in Scilit:
- Elevated C-Reactive Protein Levels in Overweight and Obese AdultsJAMA, 1999
- C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial DysfunctionArteriosclerosis, Thrombosis, and Vascular Biology, 1999
- Occurrence of Hyperhomocysteinemia 1 Year after Gastroplasty for Severe ObesityJournal of Clinical Endocrinology & Metabolism, 1999
- Complications Following Swedish Adjustable Gastric Banding: A Long-Term Follow-upObesity Surgery, 1999
- The Effect of Age on the Association between Body-Mass Index and MortalityNew England Journal of Medicine, 1998
- Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy MenNew England Journal of Medicine, 1997
- Body Weight and Mortality among WomenNew England Journal of Medicine, 1995
- Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.JCI Insight, 1995
- Gastric Banding for Morbid Obesity: Initial Experience with a New Adjustable BandObesity Surgery, 1993
- Interleukin-6 and the acute phase responseBiochemical Journal, 1990