Pathogenesis of foot-and-mouth disease: the lung as an additional portal of entry of the virus
- 1 August 1976
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 77 (2), 235-243
- https://doi.org/10.1017/s0022172400024669
Abstract
Summary: Donor cattle infected with foot and mouth disease (FMD) virus subtype O1were used to expose experimental cattle. The pharyngeal virus growth and viraemia patterns after contact exposure were quite different from those obtained after intranasal inoculation and suggested that the lower respiratory tract might provide an additional portal of entry for the virus. A tracheotomy was performed on experimental cattle to let the respiration bypass the pharynx, followed by exposure to FMD virus by different routes. The results confirmed that FMD virus can enter the bloodstream via the lung, followed by haematogenic infection of the pharynx and other replication sites simultaneously. These observations led to further experiments in which the intravenous route of infection was used to study the interaction of virus growth in the phayrnx, in other sites, and in viraemia.Keywords
This publication has 19 references indexed in Scilit:
- Pathogenesis of foot-and-mouth disease: clearance of the virus from the circulation of cattle and goats during experimental viraemiaEpidemiology and Infection, 1976
- Growth of foot-and-mouth disease virus in the upper respiratory tract of non-immunized, vaccinated, and recovered cattle after intranasal inoculationEpidemiology and Infection, 1976
- Foot-and-mouth disease virus: Plaque reduction neutralization testArchiv für die gesamte Virusforschung, 1974
- Neutralizing activity in the serum and oesophageal-pharyngeal fluid of cattle after exposure to foot-and-mouth disease virus and subsequent re-exposureArchiv für die gesamte Virusforschung, 1974
- Latent Viral Infection in Transmission of Foot-and-Mouth Disease by Contact between Infected and Susceptible CattleThe Journal of Infectious Diseases, 1971
- The growth and persistence of foot-and-mouth disease virus in the bovine mammary glandEpidemiology and Infection, 1971
- Contact Transmission of Foot-and-Mouth Disease from Infected to Susceptible CattleThe Journal of Infectious Diseases, 1971
- Inhalation, persistence and dispersal of foot-and-mouth disease virus by manEpidemiology and Infection, 1970
- Further investigations on the airborne excretion of foot-and-mouth disease virusEpidemiology and Infection, 1970
- Airborne excretion of foot-and-mouth disease virusEpidemiology and Infection, 1969