Efficacy and Safety of Ezetimibe Coadministered With Atorvastatin or Simvastatin in Patients With Homozygous Familial Hypercholesterolemia
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- 28 May 2002
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Circulation
- Vol. 105 (21), 2469-2475
- https://doi.org/10.1161/01.cir.0000018744.58460.62
Abstract
Background— Patients with homozygous familial hypercholesterolemia (HoFH) have a high incidence of cardiovascular morbidity and mortality from premature atherosclerosis, and the efficacy of pharmacological therapy has been limited. We evaluated the efficacy, safety, and tolerability of ezetimibe, a novel cholesterol absorption inhibitor, in a multicenter, double-blind, randomized trial of HoFH patients receiving atorvastatin or simvastatin.Keywords
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