Activation of phosphatidylinositol lipid‐specific phospholipase C‐β3 by G‐protein βγ subunits
- 11 January 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 315 (3), 340-342
- https://doi.org/10.1016/0014-5793(93)81190-b
Abstract
A novel member of the inositol lipid-specific phospholipase C family, PtdIns-PLCβ3, is shown to be activated by βγ subunits of the heterotrimeric GTP-binding protein, transducin. The activation is a direct effect since it is observed with the purified proteins. Furthermore, the activation is blocked by the GDP-liganded α subunit of transducin, confirming that the effect is due to free βγ subunits. The implications with respect to receptor-PtdIns-PLC coupling are discussedKeywords
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