A Study on Pigment Deposition by Intravenous Fat Emulsions

Abstract

Eleven fat emulsions containing various synthetic or vegetable oils were administered intravenously to rabbits or rats. In addition the emulsifying systems without fat were similarly tested. A pigment-lipoid complex, i.v. fat pigment, was found within the cytoplasm of the splenic reticuloendothelial cells of animals receiving coconut oil-phosphatide, cottonseed oil-nonphosphatide, cottonseed oil-phosphatide, molecularly distilled cottonseed oil-phosphatide, olive oil-phosphatide, corn oil-phosphatide, peanut oil-phosphatide, butyro olein-phosphatide, safflower oil-phosphatide or synthetic oil-nonphosphatide emulsions. No i.v. fat pigment was observed in animals receiving coconut oil-nonphosphatide emulsion or in the animals receiving the emulsifying mixture without fat.