QUANTITATIVE RELATIONSHIPS OF 4TH COMPLEMENT COMPONENT IN HUMAN CEREBROSPINAL-FLUID

Abstract

A technique for the measurement of CSF C4 [the 4th complement component] concentration in unconcentrated specimens was developed with the methods of electroimmunodiffusion and immunofixation. The method was reproducible and requires only microliter volumes of undiluted CSF. The mean value for CSF C4 concentrations in 16 neurologically normal individuals was 325 .+-. 32 .mu.g/100 ml. A positive correlation between CSF C4 concentration and the concentration of CSF albumin and total protein was observed. The positive correlation between the concentrations of CSF C4 and albumin was more clearly defined than the relationship of CSF C4 to total CSF protein.