Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex
Open Access
- 1 July 1999
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 190 (1), 141-144
- https://doi.org/10.1084/jem.190.1.141
Abstract
We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25+44− thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-β expression can be accounted for by pre-TCR–dependent signal mediation, putting into question the function of a putative pro-TCR.Keywords
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