Increased vascular response to angiotensin during ganglionic blockade

Abstract

In 10 rats blood was perfused at a constant rate into the superior mesenteric artery, and in 7 others it was similarly perfused into the right iliac artery. In both groups the vasoconstrictor response to angiotensin was tested before and during pentolinium-induced ganglionic blockade. In all but one of the superior mesenteric perfusions, the vasoconstrictor response to angiotensin increased during ganglionic blockade. In the iliac artery perfusions there was no significant increase in response, at least during the 1st hr. of ganglionic blockade. There was an increased systemic arterial blood pressure response to intravenous anglotensln during ganglionic blockade in all the experiments. It is suggested that increased vasoconstriction in certain vascular beds may be partially or completely responsible for the increased blood pressure response observed in the whole animal during ganglionic blockade.