K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.
- 1 January 1986
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 39 (8), 1066-1071
- https://doi.org/10.7164/antibiotics.39.1066
Abstract
Nocardiopsis sp. K-290 was found to produce novel metabolites, designated K-252b, c and d, which were structurally related to K-252a. These compounds were isolated from the culture broth and the physico-chemical and biochemical properties were examined. The compounds strongly inhibited protein kinase C. IC50 values (the concentrations causing 50% inhibition) for the effects of K-252b, c and d on the rat brain enzyme were 38.3, 214, and 337 nM, respectively.This publication has 5 references indexed in Scilit:
- The structures of the novel protein kinase C inhibitors K-252a, b, c and d.The Journal of Antibiotics, 1986
- K-252a, a potent inhibitor of protein kinase C from microbial origin.The Journal of Antibiotics, 1986
- Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.Journal of Biological Chemistry, 1982
- X-Ray crystal structure of staurosporine: a new alkaloid from a Streptomyces strainJournal of the Chemical Society, Chemical Communications, 1978
- A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.The Journal of Antibiotics, 1977