Catalytic, Asymmetric Mannich-Type Reactions of N-Acylimino Esters for Direct Formation of N-Acylated Amino Acid Derivatives. Efficient Synthesis of a Novel Inhibitor of Ceramide Trafficking, HPA-12
- 13 December 2001
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (1), 143-145
- https://doi.org/10.1021/ol017062u
Abstract
Catalytic, enantioselective Mannich-type reactions of N-acylimino esters for direct formation of N-acylated amino acid derivatives are described. A chiral copper catalyst prepared from Cu(OTf)2 and a chiral diamine ligand is used. A novel inhibitor of ceramide trafficking, HPA-12, is efficiently synthesized using this reaction.Keywords
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