Cytotoxic Effect of Anti‐H‐2 and Anti‐Ia Antisera on Human B and T Cells
- 1 May 1977
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 6 (5), 431-437
- https://doi.org/10.1111/j.1365-3083.1977.tb02100.x
Abstract
Anti-H-2 and anti-Ia alloimmune mouse antisera were tested by the microcytotoxicity test on human peripheral blood B- and T-cell preparations. Anti-H-2 antisera react by a higher titer and/or cytotoxicity scoring grade on B cels than on T cells. Anti-Ia antisera react practically only with B cells. It was assumed that anti-H-2 antisera contain two components. One component reacts specifically with certain HLA-A- or -B-locus antigens or other closley linked gene products. The other component reacts predominantly or only with B-cell determinants; the specificity of the latter component has not yet been studied in sufficient detail.Keywords
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