SIMULTANEOUS INFUSION OF PROSTAGLANDIN E2 ANTAGONIZES THE LUTEOLYTIC ACTION OF PROSTAGLANDIN F2α IN VIVO

Abstract
SUMMARY: Corpora lutea of ewes bearing ovarian autotransplants were infused for 4 h with prostaglandin F (PGF) (10 μg/h), PGF + PGE2 (10 μg/h of each), PGE2 (10 μg/h) or saline on day 10 of the cycle. Ovarian venous blood obtained before, during, and up to 12 h after the infusion period, was assayed for progesterone. Prostaglandin F produced an immediate, rapid and sustained decline in progesterone secretion, but infusion of PGE2 together with PGF prevented the decline until after the infusion. Progesterone secretion was unaffected by infusion of PGE2 alone. Oestrous behaviour was observed in four out of seven animals infused with PGF but in only one out of six infused with PGF + PGE2. None of the animals infused with PGE2 alone or saline only came into heat.

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