Low Dose Trimethoprim Prophylaxis in Long Term Control of Chronic Recurrent Urinary Tract Infection

Abstract
26 patients with chronic urinary tract infections (UTI) were treated with 1 tablet of 100 mg trimethoprim (TMP) once daily for up to 6 months as long term prophylaxis. The recurrence rate before prophylaxis was 26/100 months, compared to a significantly lower frequency (3.3 recurrences/100 months, pp<0.05). A 10% recovery of TMP resistant enterobacteria from rectal swabs was noted early (≤1 month) during prophylaxis, but no significant further accumulation occurred.