Genetic analysis of autoimmune type 1 diabetes mellitus in mice
- 1 June 1991
- journal article
- Published by Springer Nature in Nature
- Vol. 351 (6327), 542-547
- https://doi.org/10.1038/351542a0
Abstract
Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17.Keywords
This publication has 36 references indexed in Scilit:
- Incidence of insulin dependent diabetes in children aged under 15 years in the British Isles during 1988.BMJ, 1991
- Genetic control of autoimmunity in type 1 diabetesImmunology Today, 1990
- Genetic heterogeneity in tuberous sclerosisGenomics, 1990
- Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chainNature, 1990
- Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and RatAnnual Review of Immunology, 1990
- A primary genetic map of markers for human chromosome 10Genomics, 1988
- Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.The Journal of Experimental Medicine, 1987
- The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility ComplexScience, 1986
- A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRACell, 1985
- Construction of linkage maps with DNA markers for human chromosomesNature, 1985