Inhibition of insect juvenile hormone synthesis by phorbol 12-myristate 13-acetate
- 5 October 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 222 (2), 345-348
- https://doi.org/10.1016/0014-5793(87)80399-x
Abstract
The synthesis of insect juvenile hormone III (JH III) by isolated corpora allata of the cockroach Diploptera punctata incubated in vitro is inhibited by phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-dibutyrate and 1-oleyl-2-acetylglycerol. 4α-Phorbol 12,13-didecanoate and diolein are inactive. The inhibitory effect of phorbol 12-myristate 13-acetate is fully reversed by 2E,6E-farnesol or by 2E,6E-farnesoic acid. It is highest in corpora allata that are past their peak in secretory activity or that have been inhibited by injections of 20-hydroxyecdysone. This effect of phorbol esters implicates protein kinase C in the regulation of insect corpus allatum activityKeywords
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