Preparation and Evaluation of111In-Labeled Leukocytes as an Abscess Imaging Agent in Dogs

Abstract

Leukocytes labeled with ¹¹¹ln chelated with 8-hydroxyquinoline were evaluated as an abscess imaging agent in dogs. The labeling technique is simple and offers 75–95% efficiency. The half-clearance time of the labeled leukocytes is 6–10 hours, and the target-to-blood activity ratios are higher than those of other compounds now In use. The authors suggest that ¹¹¹In-labeled leukocyes replace ⁶⁷Ga citrate as a routine abscess imaging agent.