THE RESPONSE OF JEJUNUM AND ILEUM TO FOOD AND ENTEROCRININ

Abstract

Auto-transplants of jejunum and lieum in the belly wall of dogs were used for the production of succus entericus. In normally innervated fistulas of this type, feeding diminished both enzyme conc. and total production. This inhibition persisted in the jejunum for 6 or 7 hrs. and in the ileum for at least 8 hrs. Section of the extrinsic nerves abolished the inhibition. This result is interpreted to mean that there is an antagonism between the action of the extrinsic nerves and the enterocrinin produced in the intact intestine during the process of digestion. The adm. of enterocrinin either intravenously or subcutaneously overcomes the normal inhibition and this effect is accentuated by denervation. The hormone injs. bring about increased conc. and total production of the 4 enzymes present in succus entericus; chloride, pH and total CO2 are not affected.