The Effect of Metoprolol —a New Selective Adrenergic β1‐receptor Blocking Agent—in Mild Hypertension
- 12 January 1976
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 199 (1-6), 65-70
- https://doi.org/10.1111/j.0954-6820.1976.tb06692.x
Abstract
Metoprolol, a new selective adrenergic .beta.1-receptor blocking drug, was compared to placebo in a series of 24 women who previously had taken alprenolol and propranolol during a cross-over study. Blood pressure (BP) and heart rate (HR) were significantly reduced during metoprolol treatment compared to placebo. The occurrence of side-effects was similar during treatment with metoprolol and placebo. After the cross-over study the patients continued on metoprolol for more than 2 yr, except for short periods on placebo or propranolol. During this follow-up period BP remained at a similar level when the metoprolol dose was unchanged. Dose reduction (from 50 or 100 mg 3 times daily to 50 or 100 mg twice daily) caused no, or only a very slight, increase in BP. No side-effects were reported during long-term treatment.This publication has 17 references indexed in Scilit:
- Comparison between Metoprolol and Propranolol as Antihypertensive AgentsActa Medica Scandinavica, 1976
- Comparative bioavailability and effect studies on metoprolol* administered as ordinary and slow‐release tablets in single and multiple dosesActa Pharmacologica et Toxicologica, 1975
- A LONG‐TERM STUDY OF THE ANTIHYPERTENSIVE EFFECT OF ALPRENOLOLActa Medica Scandinavica, 1974
- LONG‐TERM EFFECT OF ALPRENOLOL AS ANTIHYPERTENSIVE AGENTActa Medica Scandinavica, 1974
- Comparative study of alprenolol and methyldopa in previously untreated essential hypertension.Heart, 1973
- Pharmacological studies of two new cardioselective adrenergic beta-receptor antagonistsLife Sciences, 1973
- COMPARISON BETWEEN ALPRENOLOL AND PROPRANOLOL AS ANTIHYPERTENSIVE AGENTSActa Medica Scandinavica, 1972
- Controlled Trial of Propranolol in HypertensionBMJ, 1970
- Propranolol as an antihypertensive agentAmerican Heart Journal, 1970
- Differentiation of receptors responsive to isoproterenolLife Sciences, 1967