Seroprevalence of Neutralizing Antibodies to Adenovirus Type 5 among Children in India: Implications for Recombinant Adenovirus-Based Vaccines
- 1 August 2007
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 14 (8), 1053-1055
- https://doi.org/10.1128/cvi.00173-07
Abstract
We determined the levels of adenovirus 5 (Ad5) neutralizing antibodies in children in India less than 2 years of age. The results clearly show an age-dependent increase in Ad5-specific immunity, with 7- to 12-month-old children having the lowest levels of Ad5 immunity. This opens up the scope for the use of recombinant Ad5-based vaccines in this age group.Keywords
This publication has 21 references indexed in Scilit:
- Gene Transduction and Cell Entry Pathway of Fiber-Modified Adenovirus Type 5 Vectors Carrying Novel Endocytic Peptide Ligands Selected on Human Tracheal Glandular CellsJournal of Virology, 2004
- An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropismVirology, 2004
- Adenovirus types 5 and 35 seroprevalence in AIDS risk groups supports type 35 as a vaccine vectorAIDS, 2004
- Prevalence of Neutralizing Antibodies to Adenoviral Serotypes 5 and 35 in the Adult Populations of The Gambia, South Africa, and the United StatesClinical and Vaccine Immunology, 2004
- Identification of Adenovirus (Ad) Penton Base Neutralizing Epitopes by Use of Sera from Patients Who Had Received Conditionally Replicative Ad (Ad dl 1520) for Treatment of Liver TumorsJournal of Virology, 2003
- A Replication Competent Adenovirus 5 Host Range Mutant-Simian Immunodeficiency Virus (SIV) Recombinant Priming/Subunit Protein Boosting Vaccine Regimen Induces Broad, Persistent SIV-Specific Cellular Immunity to Dominant and Subdominant Epitopes in Mamu-A*01 Rhesus MacaquesThe Journal of Immunology, 2003
- Construction and Characterization of Adenovirus Serotype 5 Packaged by Serotype 3 HexonJournal of Virology, 2002
- Prevalence of adenovirus types 3 and 7 antibodies in Singapore.2001
- Development of a preventive vaccine for Ebola virus infection in primatesNature, 2000
- Neutralizing antibodies against 33 human adenoviruses in normal children in RomeEpidemiology and Infection, 1982