Experience with synthetic secretin in the treatment of duodenal ulcer
- 1 November 1976
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 21 (11), 921-925
- https://doi.org/10.1007/bf01071902
Abstract
Hospitalized male patients with endoscopically verified duodenal ulcer were studied to determine the effect of secretin on the clinical course of their disease. Seven patients received synthetic porcine secretin, 333 μg subcutaneously every 4 hr for 10 days, and 6 patients received placebo injections on the same schedule. Repeat endoscopy was performed within 48 hr of completing the 10-day treatment period. The trial was discontinued because of transient, asymptomatic, hyperamylasemia in secretin-treated patients. Although significant gastric alkalinization could be reproducibly demonstrated in secretin-treated patients, secretin was not more effective than placebo in relieving pain or healing duodenal ulcer. However, because the number of patients was small, definitive conclusions regarding efficacy of secretin in ulcer treatment could not be drawn.This publication has 17 references indexed in Scilit:
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