Standardization initiatives in the (eco)toxicogenomics domain: a review
Open Access
- 1 December 2004
- journal article
- review article
- Published by Wiley in Comparative and Functional Genomics
- Vol. 5 (8), 633-641
- https://doi.org/10.1002/cfg.447
Abstract
The purpose of this document is to provide readers with a resource of different ongoing standardization efforts within the ‘omics’ (genomic, proteomics, metabolomics) and related communities, with particular focus on toxicological and environmental applications. The review includes initiatives within the research community as well as in the regulatory arena. It addresses data management issues (format and reporting structures for the exchange of information) and database interoperability, highlighting key objectives, target audience and participants. A considerable amount of work still needs to be done and, ideally, collaboration should be optimized and duplication and incompatibility should be avoided where possible. The consequence of failing to deliver data standards is an escalation in the burden and cost of data management tasks.Keywords
Funding Information
- ILSI-HESI Genomics Committee
This publication has 20 references indexed in Scilit:
- Data standards for 'omic' scienceNature Biotechnology, 2004
- CEBS object model for systems biology data, SysBio-OMBioinformatics, 2004
- Toxicogenomics in risk assessment: an overview of an HESI collaborative research program.Environmental Health Perspectives, 2004
- The HUPO PSI's Molecular Interaction format—a community standard for the representation of protein interaction dataNature Biotechnology, 2004
- ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research.Environmental Health Perspectives, 2003
- The MGED ontology: a framework for describing functional genomics experimentsComparative and Functional Genomics, 2003
- Microarray databases: standards and ontologiesNature Genetics, 2002
- An open letter to the scientific journalsBioinformatics, 2002
- Standards for Microarray DataScience, 2002
- Gene Expression Omnibus: NCBI gene expression and hybridization array data repositoryNucleic Acids Research, 2002