Serum Co60 Vitamin B12 Binding Capacity in Some Hematologic Disorders.

Abstract

A survey of in vitro Co60 vitamin B12 binding capacity of serum from patients with various hematological diseases is presented. Results are compared with previous studies employing microbiological assay and with measurements of serum content as well as binding capacity for the vitamin. These data confirm earlier findings of elevated binding capacity in acute and chronic myelocytic leukemia and in polycythemia vera. An increased binding capacity in some cases of chronic lymphocytic leukemia and idiopathic neutropenia is noted for the first time.