Declining semen quality and increasing incidence of testicular cancer: is there a common cause?
- 1 October 1995
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 103 (suppl 7), 137-139
- https://doi.org/10.1289/ehp.95103s7137
Abstract
Male reproduction has been given little attention in science and in medical practice. However, a recent metaanalysis on semen quality, which clearly pointed to a decrease over the past 50 years, has been repeatedly quoted. Three recent reports have found that semen quality has declined among candidate semen donors during the past 20 years. The evidence of decline in the quality of semen is not the only indicator that the human testis is at risk. During the past 50 years, cancer of the testis has also become more common. This is a disorder of young men, and it is associated with a high rate of other abnormalities of the testis including undescended testis and poor semen quality. Furthermore, the incidence of both hypospadias and undescended testis has been reported to be rising in the general population. We believe that the evidence of declining semen quality should be seen in the light of these trends in other reproductive disorders of men. However, the etiology is unknown. A recent hypothesis that links the trends in the health of the male reproductive system to xenoestrogens in the environment is discussed.Keywords
This publication has 19 references indexed in Scilit:
- Functional toxicology: a new approach to detect biologically active xenobiotics.Environmental Health Perspectives, 1993
- Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?The Lancet, 1993
- Evidence for decreasing quality of semen during past 50 years.BMJ, 1992
- Parental fertility and infant hypospadias: An international case‐control studyTeratology, 1991
- The Epidemiology of CryptorchidismHormone Research, 1988
- Proliferation of Sertoli cells during development of the human testis assessed by stereological methodsInternational Journal of Andrology, 1987
- Changes in testicular cancer in ScotlandEuropean Journal of Cancer and Clinical Oncology, 1987
- Carcinoma‐in‐situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytomaInternational Journal of Andrology, 1987
- A Joint International Study on the Epidemiology of HypospadiasActa Paediatrica, 1986
- APPARENT DOUBLING OF FREQUENCY OF UNDESCENDED TESTIS IN ENGLAND AND WALES IN 1962-81The Lancet, 1984