Effect of pyridines on phenotypic properties of Bordetella pertussis
- 1 November 1982
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 38 (2), 548-553
- https://doi.org/10.1128/iai.38.2.548-553.1982
Abstract
Several conditions of growth of B. pertussis cause a reversible phenotypic alteration in properties termed modulation. Growth in medium containing nicotinic acid induces normal (X-mode) cells to change to modulated (C-mode) cells. Several pyridines and compounds resembling pyridines were examined for their ability to affect modulation, using envelope protein patterns and serological reactivity as indicators of modulation. 6-Chloronicotinic acid and quinaldic acid were more effective modulating stimuli than was nicotinic acid on a molar basis. Both 2-chloronicotinamide and isoniazid interfered with nicotinic acid-induced modulation and can be called antimodulators. Picolinic acid inhibited growth.This publication has 17 references indexed in Scilit:
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