Ir‐Catalysed Asymmetric Hydrogenation: Ligands, Substrates and Mechanism
- 5 April 2006
- journal article
- Published by Wiley in Chemistry – A European Journal
- Vol. 12 (12), 3194-3200
- https://doi.org/10.1002/chem.200500755
Abstract
Relatively air and moisture tolerant cationic iridium complexes, with chiral non-racemic N,P-ligands and weakly coordinating counter ions, are efficient catalysts in the asymmetric hydrogenation of olefins. Unfunctionalised olefins are particularly difficult substrates because, in general, a polar group adjacent to the alkene bond is required for high catalytic activity and enantioselectivity. The applicability towards a variety of substrates and choice of ligands reported thus far in the literature, as well as the mechanism, selectivity issues and the importance of the anion are also discussed.Keywords
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