Direct effects of carbachol on membrane potential and ion activities in leech glial cells
- 1 January 1988
- Vol. 1 (2), 165-167
- https://doi.org/10.1002/glia.440010209
Abstract
Ion-selective double-barreled microelectrodes were used to measure the activities of intracellular K+ and Na+ (a, a) and the membrane potential (Em) in neuropile glial cells as well as extracellular K+ (a) in the neuropile of segmental ganglia in the leech, Hirudo medicinalis. Bath-application of carbachol resulted in a prominent membrane depolarization. This depolarization was accompanied by transient increases of a and a, whereas a decreased. It is suggested that the carbachol-induced depolarization and the underlying ion activity changes are due to activation of an acetylcholine receptor-coupled cation channel in the membrane of the neuropile glial cells.Keywords
This publication has 9 references indexed in Scilit:
- γ-Aminobutyric acid opens Cl-channels in cultured astrocytesBrain Research, 1987
- Ion activities and potassium uptake mechanisms of glial cells in guinea‐pig olfactory cortex slices.The Journal of Physiology, 1987
- Different types of potassium transport linked to carbachol and γ-aminobutyric acid actions in rat sympathetic neuronsNeuroscience, 1984
- Potassium activity in leech neuropile glial cells changes with external potassium concentrationBrain Research, 1983
- Ionic mechanism of a hyperpolarizing 5-hydroxytryptamine effect on leech neuropile glial cellsBrain Research, 1982
- Extracellular Potassium in Neuropile and Nerve Cell Body Region of the Leech Central Nervous SystemJournal of Experimental Biology, 1980
- Fluorescence marking of neuropile glial cells in the central nervous system of the leech Hirudo medicinalisCell and tissue research, 1980
- Electrical response of glioma cells to acetylcholineBrain Research, 1976
- Effects of acetylcholine and carbamylcholine on the axon and Schwann cell electrical potentials in the squid nerve fibreThe Journal of Physiology, 1974