MATERNAL-AGE EFFECT IN ANEUPLOIDY - DOES ALTERED EMBRYONIC SELECTION PLAY A ROLE
- 1 January 1982
- journal article
- research article
- Vol. 34 (4), 558-565
Abstract
The age of mothers of children with trisomy 21 (47,+21) is elevated no matter if the extra chromosome is of maternal or paternal origin, and it was postulated that decreasing maternal selection against affected conceptuses with advancing age might explain this observation. Since the absence of sufficient data on 47,+21 abortuses precludes a direct test of this hypothesis, an indirect approach was taken. Pooled data from spontaneous abortions and live births with autosomal trisomies, XXY and XXX, were examined to determine the natural history of these aneuploid conceptuses and its relation to maternal age. The results are consistent with decreasing embryonic selection in older women.This publication has 28 references indexed in Scilit:
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