Dihydromevinolin,a potent hypocholesterolemic metabolite produced by Aspergillus terreus.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (5), 507-512
- https://doi.org/10.7164/antibiotics.34.507
Abstract
A new, potent hypocholesterolemic agent is produced by cultures of A. terreus. The isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in 3 biological assays are given: in vitro inhibition of HMG[3-hydroxy-3-methylglutaryl]-CoA reductase [EC 1.1.1.34], inhibition of sterol synthesis in cell cultures [mouse L-M cells] and inhibition of cholesterol synthesis in vivo in rats.This publication has 5 references indexed in Scilit:
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